After 3 years of exciting cooperative research the project BACRNAs - funded by the Commission of the European Communities - expires and the website will shortly convert to a communication platform of the BACRNAs team for future projects.
Non-coding RNAs in Bacterial Pathogenicity
The BACRNAs team studies the role of non-coding RNAs (ncRNAs) in the regulation of bacterial virulence with the long-term objective to generate fundamental knowledge that can be directly applicable for therapeutic therapies to combat bacterial infections.
Development of tools for the subsequent identification, characterisation and structural analysis of ncRNAs in pathogenic bacteria as well as identification and validation of targets controlled by ncRNAs involved in virulence.
Investigation of regulatory mechanisms of ncRNAs involved in bacterial pathogenicity and RNA structure in E. coli, Pseudomonas aeruginosa, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus and Streptococcus pyogenes.
Identification of novel targets suitable for antimicrobial drug development and investigation of possible inhibiting or repressing non-essential virulence factors, which would lead to loss of pathogenicity but not necessarily killing of the pathogen.
