Giuseppe Novelli, MD

Professor, Head of Division of Medical Genetics and Coordinator of Lipodystrophy Clinical Research Staff

Research

  • Genetics and genomics of rare Muscular Disorders
  • Identification of a novel autosomal dominant vacuolar neuromyopathy
  • cDNA array and analysis of gene expression in rare diseases
  • Characterization of the molecular pathways involved in the molecular defect causing MADA
  • Definition of clinical treatment for MAD

novelli@med.uniroma2.it

The group of Giuseppe Novelli will evaluate the therapeutic response to specific PPARGamma agonists (e.g. rosiglitazone) and adipocytokines (leptin/adiponectin) in different lipodystrophy syndrome patients and will investigate the effects of subcutaneously-administered recombinant leptin in MADA patients. The group will also be involved in the development of research methodologies to elucidate the biochemical mechanisms of metabolic reactions induced by experimental drugs in patients. Additionally the group will develop a new healthcare platform for improved screening, diagnosis, follow-up and treatment of the disease.

Working Group

Paolo Sbraccia, MD, Associate Professor of Internal Medicine
Monica D’Adamo, MD
Maria Rosaria D’Apice, PhD
Francesca Gullotta, PhD student
Francesca Lombardi, PhD student

Preliminary work in 2005

Address

Dipartimento di Biopatologia e Diagnostica per Immagini
Sezione di genetica
Università di Tor Vergata
Via Montpellier 1
00133 Roma, Italia

Phone +39 062 0900 670
Fax +39 062 0900 669

Links

Universita’ di Roma Tor Vergata
Policlinico di Roma Tor Vergata